Semaglutide & Tirzepatide

What Are Semaglutide & Tirzepatide?

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist; tirzepatide is a dual agonist (GLP-1 plus gastric inhibitory polypeptide, GIP). These medications work by:

Slowing gastric emptying (you feel fuller longer)
Reducing appetite
Modulating blood sugar regulation

Because of these effects, both semaglutide and tirzepatide can lead to significant weight loss in persons with overweight or obesity, with or without type 2 diabetes.

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How Much Weight Loss Can You Expect?

Clinical trials and recent comparative studies show that tirzepatide tends to produce greater weight loss than semaglutide. Some key findings:

A large U.S. clinical cohort study compared people using semaglutide vs tirzepatide. Most achieved at least 5% weight loss; those using tirzepatide were much more likely to achieve 10% or 15% reductions. Weight loss differences at 3, 6, and 12 months were significantly in favor of tirzepatide.
In a head-to-head trial among participants with obesity but without type 2 diabetes, mean weight loss at about 72 weeks was ~20% for tirzepatide vs ~14% for semaglutide.
With semaglutide (at its authorized obesity dose), many patients in trials lost around 14-15% of starting body weight over ~68-72 weeks vs placebo.

Individual results vary depending on starting weight, dose, duration, lifestyle, and metabolic factors.

Who Is a Good Candidate?

Semaglutide or tirzepatide may be appropriate if you:

Have a body mass index (BMI) in the range qualifying for medical weight management
Are committed to lifestyle changes (diet, physical activity, behavior)
Do not have contraindications such as certain pancreatic or gallbladder disorders
Have no allergies to the medications or excipients

These drugs are not recommended in pregnancy, while breastfeeding, or in people with certain medical conditions unless cleared by a physician. Off-label use or compounded/unregulated products should be avoided.

Photo of a woman measuring her waistline after weight loss injections

Duration of Results & Maintaining Weight Loss

Many patients using semaglutide or tirzepatide see major weight reduction over ~1 year, especially when combined with lifestyle changes.
To maintain weight loss, ongoing treatment often continues; stopping abruptly tends to lead to some weight regain.
Long-term success is supported by a structured plan: nutrition, physical activity, behavior therapy, monitoring, and follow-ups.

Why Choose Modern Dose

Medical oversight from providers experienced in prescribing semaglutide & tirzepatide
Personalized plans with dose titration to maximize results & minimize side effects
Integrated support: nutrition, behavioral counseling, monitoring labs
Transparent approach: discussing risks, costs, insurance/coverage options

How soon will I see results?

Some weight loss begins in the first few weeks; more substantial results (e.g. >10% of body weight) typically appear over several months, often by 6-12 months depending on dose and adherence.

Are these injections painful?

They are administered via subcutaneous injection (under the skin). Discomfort is usually mild; providers use techniques and tools to make injections as tolerable as possible.